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PUBLICATIONS

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  1. Kenta Fujimoto, Yuki Shibata, Takashi Hasebe. (2023). Thyroid hormone-activated signaling pathways are essential for development of intestinal stem cells. J Nippon Med Sch 90(3):246-52. 

  2. Takashi Hasebe, Kenta Fujimoto, Atsuko Ishizuya-Oka. (2023). Stem cell development involves divergent thyroid hormone receptor subtype expression and epigenetic modifications in the amphibian intestine during metamorphosis. Vitam Horm 122:1-22

  3. Takashi Hasebe, Kenta Fujimoto, Atsuko Ishizuya-Oka. (2022). Essential roles of YAP-TEAD complex in adult stem cell development during thyroid hormone-induced intestinal remodeling of Xenopus laevis. Cell Tissue Res 388: 313-329.

  4. Takashi Hasebe, Kenta Fujimoto, Atsuko Ishizuya-Oka. (2020) Thyroid hormone-induced expression of Foxl1 in subepithelial fibroblasts correlates with adult stem cell development during Xenopus intestinal remodeling. Sci Rep 10: 20715

  5. Takashi Hasebe, Kenta Fujimoto, Daniel R. Buchholz, Atsuko Ishizuya-Oka. (2020) Stem cell development involves divergent thyroid hormone receptor subtype expression and epigenetic modifications in the Xenopus metamorphosing intestine. Gen Comp Endocrinol 292: 113441

  6. Kenta Fujimoto, Takashi Hasebe, Mitsuko Kajita, Atsuko Ishizuya-Oka. (2018) Expression of hyaluronan synthases upregulated by thyroid hormone is involved in intestinal stem cell development during Xenopus laevis metamorphosis. Dev Genes Evol 228:267-273

  7. Yuto Sakane, Midori Iida, Takashi Hasebe, Satoshi Fujii, Daniel R. Buchholz, Atsuko Ishizuya-Oka, Takashi Yamamoto, Ken-ichi T. Suzuki. (2018) Functional analysis of thyroid hormone receptor beta in Xenopus tropicalis founders using CRISPR-Cas. Biol Open 7(1) pii: bio030338

  8. Takashi Hasebe, Kenta Fujimoto, Mitsuko Kajita and Atsuko Ishizuya-Oka. (2017) Essential roles of thyroid hormone-regulated hyaluronan/CD44 signaling in adult stem cell development during Xenopus laevis intestinal remodeling. Stem Cells 35: 2175-2183

  9. Takashi Hasebe, Kenta Fujimoto, Mitsuko Kajita, Liezhen Fu, Yun-Bo Shi and Atsuko Ishizuya-Oka. (2017) Thyroid hormone-induced activation of Notch signaling is required for adult intestinal stem cell development during Xenopus laevis metamorphosis. Stem Cells 35:1028-1039

  10. Takashi Hasebe, Kenta Fujimoto, Mitsuko Kajita and Atsuko Ishizuya-Oka. (2016) Thyroid hormone activates Wnt/beta-catenin signaling involved in adult epithelial development during intestinal remodeling in Xenopus laevis. Cell Tissue Res 365:309-318

  11. Luan Wen, Takashi Hasebe, Thomas C. Miller, Atsuko Ishizuya-Oka and Yun-Bo Shi. (2015) A requirement for hedgehog signaling in thyroid hormone-induced postembryonic intestinal remodeling. Cell & Bioscience 5: 13

  12. Atsuko Ishizuya-Oka, Mistuko Kajita and Takashi Hasebe. (2014). Thyroid hormone-regulated Wnt5a/Ror2 signaling is essential for dedifferentiation of larval epithelial cells into adult stem cells in the Xenopus laevis intestine. PLoS ONE 9(9): e107611.

  13. Jun Fujii, Maho Kodama, Akira Oike, Yasuki Matsuo, Mi-Sook Min, Takashi Hasebe, Atsuko Ishizuya-Oka, Koichi Kawakami, Masahisa Nakamura. (2014). Involvement of androgen receptor in sex determination in an amphibian species. PLoS ONE 9(5): e93655.

  14. Guihong Sun, Rachel A. Heimeier, Liezhen Fu, Takashi Hasebe, Biswajit Das, Atsuko Ishizuya-Oka, Yun-Bo Shi. (2013). Expression profiling of intestinal tissues implicates novel genes and pathways essential for adult stem cell development. Endocrinology 154: 4396-4407

  15. Takashi Hasebe, Liezhen Fu, Thomas C. Miller, Yu Zhang, Yun-Bo Shi and Atsuko Ishizuya-Oka. (2013). Thyroid hormone-induced cell-cell interactions are required for the development of adult intestinal stem cells. Cell Biosci. 3: 18.

  16. Thomas C. Miller, Guihong Sun, Takashi Hasebe, Liezhen Fu, Rachel A. Heimeier, Biswajit Das, Atsuko Ishizuya-Oka and Yun-Bo Shi. (2013). Tissue-specific upregulation of MDS/EVI gene transcripts in the intestine by thyroid hormone during Xenopus metamorphosis. PLoS One 8: e55585.

  17. Atsuko Ishizuya-Oka and Takashi Hasebe. (2013). Establishment of intestinal stem cell niche during amphibian metamorphosis. Curr. Top. Dev. Biol. 103: 305-327.

  18. Takashi Hasebe, Mitsuko Kajita, Liezhen Fu, Yun-Bo Shi and Atsuko Ishizuya-Oka. (2012). Thyroid hormone-induced sonic hedgehog signal up-regulates its own pathway in a paracrine manner in the Xenopus laevis intestine during metamorphosis. Dev. Dyn. 241, 403-414.

  19. Takashi Hasebe, Mitsuko Kajita, Mari Iwabuchi, Keita Ohsumi and Atsuko Ishizuya-Oka. (2011). Thyroid hormone-regulated expression of nuclear lamins correlates with dedifferentiation of intestinal epithelial cells during Xenopus laevis metamorphosis. Dev. Genes Evol. 221: 199-208.

  20. Yun-Bo Shi, Takashi Hasebe, Liezhen Fu, Kenta Fujimoto and Atsuko Ishizuya-Oka. (2011). The development of the adult intestinal stem cells: Insights from studies on thyroid hormone-dependent amphibian metamorphosis. Cell Biosci. 1: 30.

  21. Natsuki Motoi*, Takashi Hasebe*, Ken-ichi T. Suzuki and Atsuko Ishizuya-Oka. (2011). Spatiotemporal expression profile of no29/nucleophosmin3 in the intestine of Xenopus laevis during metamorphosis. Cell Tissue Res. 344: 445-453. (*equal contributors)

  22. Takashi Hasebe, Daniel R. Buchholz, Yun-Bo Shi and Atsuko Ishizuya-Oka. (2011). Epithelial-connective tissue interactions induced by thyroid hormone receptor are essential for adult stem cell development in the Xenopus laevis intestine. Stem Cells 29: 154-161.

  23. Masakazu Fujiwara, Takashi Hasebe, Mitsuko Kajita, Atsuko Ishizuya-Oka, Mohammad Ghazizadeh and Oichi Kawanami. (2011). RCAN1 regulates vascular branching during Xenopus laevis angiogenesis. J. Vasc Res. 48: 104-118.

  24. Guihong Sun*, Takashi Hasebe*, Kenta Fujimoto*, Rosemary Lu, Liezhen Fu, Hiroki Matsuda, Mitsuko Kajita, Atsuko Ishizuya-Oka and Yun-Bo Shi. (2010). Spatio-temporal expression profile of stem cell-associated gene LGR5 in the intestine during thyroid hormone-dependent metamorphosis in Xenopus laevis. PLoS One 5: e13605. (*equal contributors)

  25. Atsuko Ishizuya-Oka, Takashi Hasebe and Yun-Bo Shi. (2010). Apoptosis in amphibian organs during metamorphosis. Apoptosis 15: 350-364.

  26. Smita Mathew, Liezhen Fu, Takashi Hasebe, Atsuko Ishizuya-Oka and Yun-Bo Shi. (2010). Tissue-dependent induction of apoptosis by matrix metalloproteinase stromelysin-3 during amphibian metamorphosis. Birth Defects Res. C Embryo Today 90: 55-66.

  27. Yonggang Wang, Debaditya Mukhopadhyay, Smita Mathew, Takashi Hasebe, Rachel A. Heimeier, Yoshiaki Azuma, Nagamalleswari Kolli, Yun-Bo Shi, Keith D. Wilkinson, Mary Dasso. (2009). Identification and developmental expression of Xenopus laevis SUMO proteases. PLoS One 4:e8462.

  28. Scott A. Rankin, Takashi Hasebe, Aaron M. Zorn and Daniel R. Buchholz. (2009). Improved Cre reporter transgenic Xenopus. Dev. Dyn. 238: 2401-2408. ***DD ArtPix (238(12): fvii, Dec. 2009)

  29. Atsuko Ishizuya-Oka, Takashi Hasebe, Daniel R. Buchholz, Mitsuko Kajita, Liezhen Fu and Yun-Bo Shi. (2009). The origin of the adult intestinal stem cells induced by thyroid hormone in Xenopus laevis. FASEB J. 23: 2568-2575.

  30. Hiroki Matsuda, Bindu D. Paul, Cheol Young Choi, Takashi Hasebe and Yun-Bo Shi. (2009). Novel functions of protein arginine methyltransferase 1 in thyroid hormone receptor-mediated transcription and in the regulation of metamorphic rate in Xenopus laevis. Mol. Cell. Biol. 29: 745-757.

  31. Takashi Hasebe, Mitsuko Kajita, Yun-Bo Shi and Atsuko Ishizuya-Oka. (2008). Thyroid hormone-upregulated hedgehog interacting protein is involved in larval-to-adult intestinal remodeling by regulating sonic hedgehog signaling pathway in Xenopus laevis. Dev. Dyn. 237: 3006-3015.

  32. Atsuko Ishizuya-Oka and Takashi Hasebe. (2008). Sonic hedgehog and bone morphogenetic protein-4 signaling pathway involved in epithelial cell renewal along the radial axis of the intestine. Digestion 77 Suppl 1:42-47.

  33. Yun-Bo Shi, Liezhen Fu, Takashi Hasebe and Atsuko Ishizuya-Oka. (2007). Regulation of ECM remodeling and cell fate determination by matrix metalloproteinase strmoelysin-3 during thyroid hormone-dependent postembryonic development. Pharmacol. Ther. 116: 391-400.

  34. Takashi Hasebe, Mitsuko Kajita, Kenta Fujimoto, Yoshio Yaoita and Atsuko Ishizuya-Oka. (2007). Expression profiles of the duplicated matrix metalloproteinase-9 genes suggest their different roles in apoptosis of larval intestinal epithelial cells during Xenopus laevis metamorphosis. Dev. Dyn. 236: 2338-2345.

  35. Liezhen Fu*, Takashi Hasebe*, Atsuko Ishizuya-Oka and Yun-Bo Shi. (2007). Roles of matrix metalloproteinases and ECM remodeling during thyroid hormone-dependent intestinal metamorphosis in Xenopus laevis. Organogenesis 3: 14-19. (*equal contributors)

  36. Takashi Hasebe, Rebecca Hartman, Liezhen Fu, Tosikazu Amano and Yun-Bo Shi. (2007). Evidence for a cooperative role of gelatinase A and membrane type-1 matrix metalloproteinase during Xenopus laevis development. Mech. Dev. 124: 11-22.

  37. Atsuko Ishizuya-Oka, Takashi Hasebe, Katsuhiko Shimizu, Kenichi Suzuki and Shuichi Ueda. (2006). Shh/BMP-4 signaling pathway is essential for intestinal epithelial development during Xenopus larval-to-adult remodeling. Dev. Dyn. 235: 3240-3249.

  38. Takashi Hasebe, Rebecca Hartman, Hiroki Matsuda and Yun-Bo Shi. (2006). Spatial and temporal expression profiles implicate the involvement of gelatinase A and membrane type 1 matrix metalloproteinase in amphibian metamorphosis. Cell Tissue Res. 324: 105-116.

  39. Takashi Hasebe, Kuniaki Umezawa, Minoru Sugita, Takeo Iwata, Kazutoshi Yamamoto, Takashi Obinata and Sakae Kikuyama. (2003). Postmetamorphic changes in parvalbumin expression in the hindlimb skeletal muscle of the bullfrog, Rana catesbeiana. Biochim. Biophys. Acta. 1649: 42-48.

  40. Takashi Hasebe, Takeo Iwata, Kazutoshi Yamamoto, Takashi Obinata and Sakae Kikuyama. (2002). Expression of parvalbumin isoforms in the postmetamorphic bullfrog, Rana catesbeiana. In “Proceedings of the 21st Conference of European Comparative Endocrinologists”, (Keller R., Dircksen H., Sedlmeier D., Vaudry H. eds.) pp. 523-526.

  41. Takashi Hasebe, Hiroyuki Oshima, Kosuke Kawamura and Sakae Kikuyama. (1999). Rapid and selective removal of larval erythrocytes from the systemic circulation during metamorphosis of the bullfrog Rana catesbeiana. Dev. Growth Differ. 41: 639-643.

  42. Takashi Hasebe, Kosuke Kawamura and Sakae Kikuyama. (1998). Genomic DNA fragmentation in red blood cells of the bullfrog (Rana catesbeiana) during metamorphosis. Ann. N.Y. Acad. Sci. 839: 634-635.

  43. Takashi Hasebe, Hiroyuki Oshima, Kosuke Kawamura and Sakae Kikuyama. (1997). Changes in the genomic DNA of red blood cells (RBCs) and replacement of the RBC population during metamorphosis of the bullfrog. In “Advances in Comparative Endocrinology”, (Kawashima, S. and Kikuyama, S. eds.) pp.393-396.

  44. Takashi Hasebe, Kosuke Kawamura and Sakae Kikuyama. (1996). Genomic DNA fragmentation in red blood cells of the bullfrog during metamorphosis. Dev. Growth Differ. 38: 605-615.

MEETING PRESENTATIONS

Invited talks

  1. Takashi Hasebe, Kenta Fujimoto, Daniel R. Buchholz and Atsuko Ishizuya-Oka. Signaling pathways essential for thyroid hormone-induced adult stem cell development during intestinal remodeling of Xenopus laevis. 6th Bienniel NASCE Virtual Meeting (May, 2021).

  2. Takashi Hasebe and Atsuko Ishizuya-Oka. Molecular mechanisms of intestinal remodeling in Xenopus laevis: roles of Notch signaling. Symposium on “Amphibian Biologists in Wonderland -5”, 88th Annual Meeting of the Zoological Society of Japan (Toyama, Japan, Sep. 2017)

  3. Takashi Hasebe, Mitsuko Kajita and Atsuko Ishizuya-Oka. Notch signaling-dependent gene expression of Hairy1 and Hairy2b during adult stem cell development in the Xenopus laevis intestine. 8th International Symposium on Amphibian and Reptilian Endocrinology and Neurobiology (Okazaki, Nov. 2014)

  4. Takashi Hasebe and Atsuko Ishizuya-Oka. Transgenic study 2: Origin of the adult epithelial stem cells and mechanisms of their development in the metamorphosing intestine of Xenopus laevis. Symposium on “Amphibian Biologists in Wonderland -3”, 83rd Annual Meeting of the Zoological Society of Japan (Osaka, Japan, Sep. 2012)

  5. Takashi Hasebe and Atsuko Ishizuya-Oka. Transgenic frogs shed light on a wide variety of biological research. Symposium on “Amphibian Biologists in Wonderland; The Second Adventure”, 80th Annual Meeting of the Zoological Society of Japan (Shizuoka, Japan, Sep. 2009)

  6. Takashi Hasebe, Mitsuko Kajita and Atsuko Ishizuya-Oka. Thyroid hormone-upregulated expression of hedgehog interacting protein suggests its involvement in amphibian intestinal remodeling. 4th International Symposium on Amphibian and Reptilian Endocrinology and Neurobiology (Berkeley, CA, USA, Mar. 2007)

  7. Takashi Hasebe, Kosuke Kawamura and Sakae Kikuyama. Mechanisms of red blood cell transition in metamorphosing amphibian larvae. Symposium of 71st Annual Meeting of the Zoological Society of Japan (Tokyo, Japan, Sep. 2000)​

Oral presentations (Symposium)

  1. Takashi Hasebe, Mitsuko Kajita and Atsuko Ishizuya-Oka. Hedgehog interacting protein regulates Sonic hedgehog signaling essential for the intestinal remodeling during amphibian metamorphosis. 6th International Symposium on Amphibian and Reptilian Endocrinology and Neurobiology (Berlin, Germany, Sep. 2009)

  2. Atsuko Ishizuya-Oka and Takashi Hasebe. Intestinal remodeling during Xenopus metamorphosis: molecular aspects of tissue interactions. Symposium on “Amphibian Biologists in Wonderland”, 78th Annual Meeting of the Zoological Society of Japan (Hirosaki, Japan, Sep. 2007)

  3. Takashi Hasebe, Takashi Obinata and Sakae Kikuyama. Postmetamorphic changes in the expression of parvalbumin isoforms in the hindlimb skeletal muscle of the bullfrog, Rana catesbeiana. 3rd International Symposium on Amphibian and Reptilian Endocrinology and Neurobiology (Jeju, Korea, Nov. 2003)

Oral presentations

  1. Tsuguhide Shimodaira, Takayuki Iwaki, Kenta Fujimoto and Takashi Hasebe. Gene expression analysis of Hippo-related factor TEAD4 during intestinal remodeling of Xenopus laevis. The 93rd Annual Meeting of the Zoological Society of Japan (Tokyo, Japan, Sep. 2022)

  2. Kenta Fujimoto, Takashi Hasebe, Mitsuko Kajita and Atsuko Ishizuya-Oka. Possible roles of hyaluronan signaling in stem cell niche formation during intestinal remodeling in Xenopus laevis. The Joint Annual Meeting of 70th JSCB and 51st JSDB (Tokyo, Japan, Jun. 2018)

  3. Takashi Hasebe, Kenta Fujimoto, Mitsuko Kajita and Atsuko Ishizuya-Oka. Roles of hyaluronan/CD44 signaling in stem cell regulation during Xenopus laevis intestinal remodeling. 88th Annual Meeting of the Zoological Society of Japan (Toyama, Japan, Sep. 2017)

  4. Takashi Hasebe, Mitsuko Kajita and Atsuko Ishizuya-Oka. Roles of Notch signaling in Xenopus intestinal remodeling: expression analyses of DLL1 and DLL2. 86th Annual Meeting of the Zoological Society of Japan (Niigata, Japan, Sep 2015)

  5. Atsuhito Sekimoto, Etsuya Fukunaga, Mitsuko Kajita, Takashi Hasebe and Atsuko Ishizuya-Oka. Expression analyses of Jagged 1 and Jagged 2 during intestinal remodeling of Xenopus laevis. 85th Annual Meeting of the Zoological Society of Japan (Sendai, Japan, Sep. 2014)

  6. Takashi Hasebe, Mitsuko Kajita and Atsuko Ishizuya-Oka. Gene expression of Hairy1 and Hairy2b during intestinal remodeling of Xenopus laevis is dependent on Notch signaling. 84th Annual Meeting of the Zoological Society of Japan (Okayama, Japan, Sep. 2013)

  7. Takashi Hasebe, Mitsuko Kajita and Atsuko Ishizuya-Oka. Gene expression analysis of Hairy-1 and Hairy-2b during intestinal remodeling of Xenopus laevis. 83rd Annual Meeting of the Zoological Society of Japan (Osaka, Japan, Sep. 2012)

  8. Takashi Hasebe, Mitsuko Kajita and Atsuko Ishizuya-Oka. Expression analysis of Smoothened in the intestine during metamorphosis of Xenopus laevis. 81st Annual Meeting of the Zoological Society of Japan (Tokyo, Japan, Sep. 2010)

  9. Atsuko Ishizuya-Oka, Mitsuko Kajita and Takashi Hasebe. Origin of adult epithelial stem cells in the Xenopus laevis intestine. 79th Annual Meeting of the Zoological Society of Japan (Fukuoka, Japan, Sep. 2008) 

  10. Takashi Hasebe, Kosuke Kawamura and Sakae Kikuyama. Two-dimensional electrophoretic profiles of erythrocyte surface proteins in the bullfrog during metamorphic transition. 73rd Annual Meeting of the Zoological Society of Japan (Kanazawa, Japan, Sep. 2002) 

  11. Takashi Hasebe, Hiroyuki Oshima, Kosuke Kawamura and Sakae Kikuyama. Selective removal of larval type red blood cells in metamorphosing bullfrog tadpoles. 67th Annual Meeting of the Zoological Society of Japan (Sapporo, Japan, Sep. 1996)

  12. Takashi Hasebe, Kosuke Kawamura and Sakae Kikuyama. Fragmentation of genomic DNA in red blood cells of the bullfrog during metamorphosis. 66th Annual Meeting of the Zoological Society of Japan, (Tokyo, Japan, Sep. 1995)

Posters

  1. Takashi Hasebe, Kenta Fujimoto and Atsuko Ishizuya-Oka. Involvement of Hippo signaling pathway in intestinal remodeling of Xenopus laevis. 91st Meeting of the Zoological Society of Japan (Online, Sep. 2020)

  2. Kenta Fujimoto, Takashi Hasebe and Atsuko Ishizuya-Oka. Expression analysis of Wnt genes involved in intestinal stem cell development during Xenopus laevis metamorphosis. 91st Meeting of the Zoological Society of Japan (Online, Sep. 2020)

  3. Takashi Hasebe, Kenta Fujimoto, Daniel R. Buchholz, Atsuko Ishizuya-Oka. Divergent thyroid hormone receptor subtype expression and epigenetic modifications in the Xenopus metamorphosing intestine. 44th Annual Meeting and Symposium of Japan Society for Comparative Endocrinology (Saitama, Japan, Nov. 2019)

  4. Takashi Hasebe, Kenta Fujimoto and Atsuko Ishizuya-Oka. Expression analysis of genes involved in Hippo signaling during intestinal remodeling of Xenopus laevis. 89th Annual Meeting of the Zoological Society of Japan (Sapporo, Japan, Sep. 2018). **This meeting was not held due to the earthquake disaster. But the presentation was approved as "performed" by the ZSJ.

  5. Kenta Fujimoto, Takashi Hasebe, Mitsuko Kajita and Atsuko Ishizuya-Oka. Expression analysis of hyaluronan synthase genes during intestinal remodeling in Xenopus laevis. The 39th Annual Meeting of the Molecular Biology Society of Japan (Yokohama, Japan, Dec. 2016) 

  6. Takashi Hasebe, Kenta Fujimoto, Mitsuko Kajita, Liezhen Fu, Yun-Bo Shi, Atsuko Ishizuya-Oka. Thyroid hormone-induced activation of Notch signaling is required for intestinal remodeling during Xenopus laevis metamorphosis. The joint meeting of the 22nd International Congress of Zoology and the 87th Meeting of the Zoological Society of Japan (Okinawa, Japan, Nov. 2016)

  7. Takashi Hasebe, Mitsuko Kajita and Atsuko Ishizuya-Oka. Gene expression analysis of transcription factors Gli1-3 during intestinal remodeling of Xenopus laevis. 82nd Annual Meeting of the Zoological Society of Japan (Asahikawa, Japan, Sep. 2011)

  8. Takashi Hasebe and Atsuko Ishizuya-Oka. Expression of a dominant positive thyroid hormone receptor initiates adult epithelial development through epithelial-connective tissue interactions in the Xenopus laevis intestine. 43rd Annual Meeting for the Japanese Society of Developmental Biologists (Jointly Sponsored by the Asia-Pacific Developmental Biology Network) (Kyoto, Japan, May. 2010)

  9. Takashi Hasebe, Mitsuko Kajita and Atsuko Ishizuya-Oka. Patched-1 is transcriptionally activated in response to Sonic hedgehog signaling during intestinal remodeling of Xenopus laevis. 80th Annual Meeting of the Zoological Society of Japan (Shizuoka, Japan, Sep. 2009)

  10. Yonggang Wang, Debaditya Mukhopadhyday, Smita Mathew, Takashi Hasebe, Nagamalleswari Kolli, Yoshiaki Azuma, Yun-bo Shi, Keith Wilkinson and Mary Dasso. Cloning and characterization of Ulp/SENP family proteases from Xenopus laevis. Cold Spring Harbor Laboratory Meeting (New York, USA, Apr. 2009)

  11. Masakazu Fujiwara, Takashi Hasebe, Mohammad Ghazizadeh, Atsuko Ishizuya-Oka and Oichi Kawanami. Overexpression of Regulator of Calcineurin 1 represses vascular branching in Xenopus laevis larvae. The 6th Korea-Japan Joint Symposium on Vascular Biology and The 16th Annual Meeting of the Japan Vascular Biology and Medicine Organization Joint Meeting (Kanazawa, Japan, Dec. 2008)

  12. Masakazu Fujiwara, Takashi Hasebe, Mohammad Ghazizadeh, Atsuko Ishizuya-Oka and Oichi Kawanami. Overexpression of down syndrome critical region 1 represses vascular branching in Xenopus laevis larvae. 15th International Vascular Biology Meeting (Sydney, Australia, Jun. 2008)

  13. Takashi Hasebe, Mitsuko Kajita and Atsuko Ishizuya-Oka. Expression profile of hedgehog interacting protein suggests its involvement in the intestinal remodeling during Xenopus laevis metamorphosis. 41st Annual Meeting for the Japanese Society of Developmental Biologists (Tokushima, Japan, May 2008)

  14. Takashi Hasebe, Mitsuko Kajita, Yoshio Yaoita and Atsuko Ishizuya-Oka. Expression profiles of MMP-9 and its duplicated gene MMP-9TH during intestinal remodeling of Xenopus laevis. Joint Meeting of the Japanese Society of Developmental Biologists & the Japan Society for Cell Biology (Fukuoka, Japan, May 2007)

  15. Takashi Hasebe, Liezhen Fu, Atsuko Ishizuya-Oka and Yun-Bo Shi. Cooperation of gelatinase A and membrane type-1 matrix metalloproteinase during Xenopus development. 11th International Xenopus Conference (Chiba, Japan, Sep. 2006)

  16. Takahiro Tashiro, Takashi Hasebe, Kosuke Kawamura and Sakae Kikuyama. Proteome analysis of the bullfrog red blood cells during metamorphic transition. 76th Annual Meeting of the Zoological Society of Japan (Tsukuba, Japan, Oct. 2005)

  17. Takashi Hasebe and Yun-Bo Shi. Cloning and gene expression analysis of Xenopus membrane-type 1 matrix metalloproteinase. Gastrointestinal Tract XI: Innovations in GI Research and Therapy, FASEB SRC (Snowmass Village, CO, USA, Aug. 2005)

  18. Takashi Hasebe, Takeo Iwata, Kazutoshi Yamamoto, Takashi Obinata and Sakae Kikuyama. Changes in the expression of parvalbumin isoforms in the hindlimb skeletal muscle during the course of postmetamorphic development of the bullfrog, Rana catesbeiana. 21st Conference of European Comparative Endocrinologists (Bonn, Germany, Aug. 2002)

  19. Takashi Hasebe, Kuniaki Umezawa, Minoru Sugita, Takashi Obinata and Sakae Kikuyama. Changes in parvalbumin expression in the hind-limb muscle of metamorphosing and postmetamorphic Rana catesbeiana. 14th International Congress of Comparative Endocrinology (Sorrento, Italy, May 2001)

  20. Takashi Hasebe, Kuniaki Umezawa, Minoru Sugita, Risa Ito, Takashi Obinata and Sakae Kikuyama. Parvalbumin expression in the hindlimb muscle of the postmetamorphic bullfrog, Rana Catesbeiana. 26th Annual Meeting and Symposium of Japan Society for Comparative Endocrinology (Tokyo, Japan, Dec. 2001)

  21. Takashi Hasebe, Kuniaki Umezawa, Minoru Sugita, Risa Ito, Takashi Obinata and Sakae Kikuyama. Parvalbumin 2 expression in the hind-limb muscle of the postmetamorphic Rana catesbeiana. 72nd Annual Meeting of the Zoological Society of Japan (Fukuoka, Japan, Oct. 2001)

  22. Takashi Hasebe, Kosuke Kawamura and Sakae Kikuyama. Metamorphic changes of electrophoretic profiles of erythrocyte proteins from the bullfrog. 71st Annual Meeting of the Zoological Society of Japan (Tokyo, Japan, Sep. 2000)

  23. Takashi Hasebe, Kosuke Kawamura and Sakae Kikuyama. Electrophoretic profiles of erythrocyte proteins from the bullfrog before and after metamorphosis. 20th Conference of European Comparative Endocrinologists (Faro, Portugal, Sep. 2000)

  24. Takashi Hasebe, Kosuke Kawamura and Sakae Kikuyama. Selective removal of larval red blood cells by hepatic and splenic macrophages and changes in the electrophoretic profiles of erythrocyte proteins during metamorphosis of the bullfrog. 70th Annual Meeting of the Zoological Society of Japan (Yamagata, Japan, Sep. 1999)

  25. Takashi Hasebe, Kosuke Kawamura and Sakae Kikuyama. Changes in the electrophoretic pattern of membrane-bound proteins from red blood cells of the bullfrog during metamorphosis. 69th Annual Meeting of the Zoological Society of Japan (Hiroshima, Japan, Oct. 1998)

  26. Takashi Hasebe, Kosuke Kawamura and Sakae Kikuyama. Different electrophoretic profiles of high molecular weight proteins from larval and adult type red blood cells of the bullfrog. 19th Conference of European Comparative Endocrinologists (Nijmegen, The Netherlands, Sep. 1998)

  27. Takashi Hasebe, Hiroyuki Oshima, Kosuke Kawamura and Sakae Kikuyama. Changes in the genomic DNA of red blood cells (RBCs) and replacement of the RBC population during metamorphosis of the bullfrog. 13rd International Congress of Comparative Endocrinology (Yokohama, Japan, Nov. 1997)

  28. Takashi Hasebe, Hiroyuki Oshima, Kosuke Kawamura and Sakae Kikuyama. Selective removal of larval type red blood cells from climactic tadpoles during bullfrog metamorphosis. 68th Annual Meeting of the Zoological Society of Japan (Nara, Japan, Oct. 1997)

  29. Takashi Hasebe, Kosuke Kawamura and Sakae Kikuyama. Genomic DNA fragmentation in red blood cells of the bullfrog (Rana catesbeiana) during metamorphosis. 18th Conference of European Comparative Endocrinologists (Rouen, France, Sep. 1996)

Seminars

 

2015 Dec. "Molecular mechanisms of intestinal remodeling during Xenopus laevis metamorphosis”, at Department of Biological Science, Shizuoka University, Shizuoka, Japan

2011 Mar. “Thyroid hormone-induced tissue interactions essential for adult epithelial stem cell development during intestinal remodeling of Xenopus laevis”, at Institute of Development and Aging Sciences, Nippon Medical School, Kanagawa, Japan

2009 Jun. “Involvement of Sonic hedgehog signaling pathway in the intestinal remodeling of Xenopus laevis”, at Institute of Development and Aging Sciences, Nippon Medical School, Kanagawa, Japan

2008 Aug. “Role of Sonic hedgehog signaling pathway in the intestinal remodeling during Xenopus laevis metamorphosis”, at Department of Applied Chemistry and Biotechnology, Fukui University, Fukui, Japan

2006 Oct. “Evidence for a cooperative role of gelatinase A and membrane type-1 matrix metalloproteinase during Xenopus laevis development”, at Institute of Gerontology, Nippon Medical School, Kanagawa, Japan

2005 Nov. “Role of matrix metalloproteinases in ECM remodeling and tissue morphogenesis during frog development”, at Department of Biology, School of Education, Waseda University, Tokyo, Japan

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